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Monoplex Supplement Facts |
||
|---|---|---|
| Serving Size: 3 Capsules Servings Per Container: 30 |
||
| Amount Per Serving | Daily Value | |
| Vitamin C (Ascorbic Acid) | 1000 mg | 1666% |
| Folic Acid | 500 mcg | 125% |
| Vitamin B12 (Cyanocobalamin) | 5 mcg | 83% |
| Iron (Ferrous Fumerate) | 5 mg | 28% |
| Zinc (Oxide) | 7 mg | 47% |
| L-Lysine HCL | 500 mg | * |
| L-Glutamine | 550 mg | * |
| Deglycyrrhizinated Licorice | 175 mg | * |
| *Daily Value Not Established |
Daily Dosage: As a dietary supplement, take two capsules in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.
Monoplex Research:
Zinc - One of the most important minerals for immune function, zinc has been widely studied for prevention and treatment of infections. Low levels of zinc have been documented in patients with recurrent aphthous stomatitis, also known as canker sores (1).
In a zinc deficient patient who had not responded to any conventional medication and suffered from canker sores every month, after three months of oral zinc therapy the sores resolved and did not reappear for 1 year (2). A placebo-controlled study of oral zinc supplementation for one month demonstrated a significant reduction in sores in 40 patients with recurrent outbreaks (1). Another clinical study showed 50-100% reduction in the frequency of episodes in patients with low levels of zinc (3).
Vitamin B-12 - Physicians recommend that deficiency of vitamin B12 should also be considered in all patients with recurrent canker sores (4).
When compared to healthy controls, patients with recurrent canker sores have significantly lower levels of vitamin B12, suggesting this important vitamin may play a role in the etiology of this condition (5). Recurrent canker sores have been shown to respond positively to treatment with vitamin B12 (6).
Folic Acid (folate) - Similar to vitamin B12, folate levels have also been found to be low in patients with recurrent oral ulceration when compared to healthy controls (7).
In a study of 330 patients, numerous nutritional deficiencies, including folate, were documented (8). Corrected nutritional deficiencies showed favorable responses to supplementation, with complete remission in many of the patients.
Iron - Deficiency of iron and other nutritional deficiencies were observed in a study of 330 patients (8). Correction of the nutritional deficiencies showed favorable responses to supplementation, with complete remission in many of the patients. When taken at optimal levels, a majority of people with canker sores have more rapid healing (9).
L-Lysine - Classically known as an anti-herpes nutrient, patients suffering from canker sores may also benefit from treatment with L-lysine. Research shows that L-lysine may be clinically effective in treating recurrent aphthous ulcers (10).
Glutamine - The preferred fuel for cells of the GI tract, glutamine is an amino acid that also exerts a protective effect on the gastrointestinal lining and plays a role in immune defenses.
Glutamine is effective in treating chemotherapy-induced stomatitis (inflammation of the mucous membrane of the mouth), and relieves associated pain (11). Glutamine has also demonstrated efficacy in healing ulceration of the mouth and increases the resistance of the colonic tissue to inflammatory injury (12,13).
Vitamin C - Patients with recurrent canker sores demonstrate significantly lower levels of the antioxidants vitamin C and vitamin A in both serum and saliva (14). Studies also show that people with canker sores have lower dietary intake of foods containing vitamin C (15). Vitamin C can increase white blood cell counts needed to heal ulcerations (16).
Deglycyrrhizinated licorice (DGL) - Another natural substance commonly used to treat sores from herpes, DGL may also benefit patients with canker sores. This form of licorice blocks the metabolism of certain prostaglandins which can improve healing of mucosal tissue, important in repairing ulceration of the GI tract (17).
A clinical study showed that 75% of patients treated with a DGL mouthwash experienced 50-75% improvement of canker sores within one day followed by complete healing of the ulcers by third day (18).
Monoplex References:
- Orbak R et al. Effects of zinc treatment in patients with recurrent aphthous stomatitis. Dent Mater J 2003 Mar;22(1):21-9.
- Endre L. Recurrent aphthous ulceration with zinc deficiency and cellular immune deficiency. Oral Surg Oral Med Oral Pathol 1991 Nov;72(5):559-61.
- Merchant HW et al. Zinc sulfate supplementation for treatment of recurring oral ulcers. South Med J 1977 May;70(5):559-61.
- Weusten BL, van de Wiel A. Aphthous ulcers and vitamin B12 deficiency. Neth J Med 1998 Oct;53(4):172-5.
- Piskin S et al. Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol 2002 Jan;16(1):66-7
- Volkov I et al. Case report: Recurrent aphthous stomatitis responds to vitamin B12 treatment. Can Fam Physician 2005 Jun;51:844-5.
- Thongprasom K, Youngnak P, Aneksuk V. Hematologic abnormalities in recurrent oral ulceration. Southeast Asian J Trop Med Public Health 2002 Dec;33(4):872-7.
- Wray D et al. Nutritional deficiencies in recurrent aphthae. J Oral Pathol 1978;7(6):418-23.
- Rennie JS et al. Recurrent aphthous stomatitis. British Dental Journal 1985; 159:361-367
- Wright EF. Clinical effectiveness of lysine in treating recurrent aphthous ulcers and herpes labialis. Gen Dent 1994 Jan-Feb;42(1):40-2; quiz 51-2.
- Anderson PM, Schroeder G, Skubitz KM. Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer 1998;83:1433-9.
- Anderson PM, Ramsay NK, Shu XO, et al. Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation. Bone Marrow Transplant 1998;22:339-44.
- Israeli E et al. Prophylactic administration of topical glutamine enhances the capability of the rat colon to resist inflammatory damage. Dig Dis Sci 2004 Oct;49(10):1705-12.
- Saral Y et al. Assessment of salivary and serum antioxidant vitamins and lipid peroxidation in patients with recurrent aphthous ulceration. Tohoku J Exp Med 2005 Aug;206(4):305-12.
- Ogura M et al. A case-control study on food intake of patients with recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pahtol Oral Radiol Endod 2001 Jan;91(1):45-9.
- Bendich A. Vitamin C and immune responses. Food Technol 1987;41:112-4.
- Turpie AG, Runcie J, Thomson TJ. Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. Gut 1969;10:299-302.
- Das SK et al. Deglycyrrhizinated liquorice in aphthous ulcers. J Assoc Physicians India 1989 Oct;37(10):647.
